Marcadores de aterosclerosis temprana y síndrome metabólico en niños / Early markers for atherosclerosis and metabolic syndrome in children
Rev. méd. Chile
;
137(4): 522-530, abr. 2009. graf, tab
Article
Dans Espagnol
| LILACS
| ID: lil-518586
ABSTRACT
Background:
The high prevalence of obesity in children favors the appearance of metabolic syndrome (MS), increasing their cardiovascular risk.Aim:
To evaluate components of MS in children and to correlate them with surrogate markers of atherosclerosis andsubclinical inflammation. Material andmethods:
We studied 209 children aged 11.5 ± 2 years (50% girls, 30% prepuberal). Fifty percent had normal weight, 18% were overweight, 29% were obese and 3% were undernourished. A fasting blood sample was obtained to measure lipid levels,glucose, insulin, adiponectin and ultrasensitive C-reactive protein (usCRP). Subclinical atherosclerosis was evaluated using flow mediated dilatation of brachial artery (FMD) andcarotid intima-media thicknes (IMT). For diagnosis of MS we adapted Cooks criteria.Results:
Five percent of all children and 18% of those with overweight had MS. Children with more components had significantly higher fasting insulin and Homeostasis Model Assessment (HOMA) values. Clustering of MS components was also associated to higher values of usCRP and non significantly to lower adiponectin levels. We did not find differences in FMD. In obese children there was a tendency towards a higher IMT with clustering of MS components, although not significant.Conclusions:
Children with overweight presented a higher risk of a clustering ofMS components, which was also associated with insulin resistance and increase in ultrasensitive C reactive protein.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Syndrome métabolique X
/
Athérosclérose
Type d'étude:
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Enfant
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2009
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Pontificia Universidad Católica de Chile/CL
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