The possible role of Myosin light chain in myoblast proliferation
Biol. Res
;
42(1): 121-132, 2009. ilus
Article
Dans Anglais
| LILACS
| ID: lil-519091
ABSTRACT
Skeletal muscles have the potential to regenerate by activation of quiescent satellite cells, however, the molecular signature that governs satellite cells during muscle regeneration is not well defined. Myosin light chains (Myls) are sarcomere-related proteins as traditional regulator of muscle contraction. In this report, we studied the possible role of Myl in the proliferation of skeletal muscle-derived myoblasts. Compared to diaphragm-derived myoblasts, the extraocular muscle-derived myoblasts with lower levels of Myl proliferated faster, maintained a longer proliferation phase, and formed more final myotubes. It was found that blockading Myl with anti-Myl antibody or knockdown of Myll by siRNA targeted against Myll could enhance the myoblast proliferation and delay the differentiation of myoblasts. Our results suggested that Myl, likely Myll, can negatively affect myoblast proliferation by facilitating myoblast withdrawal from cell cycle and differentiation.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Régénération
/
Muscle diaphragme
/
Chaînes légères de myosine
/
Myoblastes
/
Prolifération cellulaire
/
Muscles oculomoteurs
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Biol. Res
Thème du journal:
Biologie
Année:
2009
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Sichuan University/CN
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS