Peritoneal and serum interleukin-18 levels are not increased in women with minimum or mild endometriosis
Braz. j. med. biol. res
; 42(11): 1039-1043, Nov. 2009. ilus
Article
de En
| LILACS
| ID: lil-529104
Bibliothèque responsable:
BR1.1
ABSTRACT
Interleukin-18 (IL-18) is a cytokine that belongs to the IL-1 family. Endometriosis is strongly associated with sub-fertility, and affects about 15 percent of women of reproductive age. IL-18 may favor the progression of endometriosis. The objective of the present study was to determine the concentration of IL-18 in the serum and peritoneal fluid of infertile women with endometriosis. Forty infertile and 25 fertile women were screened in a teaching hospital. Thirty-four infertile patients with minimal or mild endometriosis and 22 fertile controls were enrolled in the study. The primary outcome was the estimate of IL-18 levels and the secondary outcome was the correlation between serum and peritoneal levels of IL-18. There were no differences between the two groups regarding age, body mass index and levels of peritoneal fluid IL-18 (mean ± SD) 290.85 ± 173.02 pg/mL for infertile women vs 374.21 ± 330.15 pg/mL for controls; or serum IL-18 391.07 ± 119.71 pg/mL for infertile women vs 373.42 ± 129.11 pg/mL for controls. However, a positive association was found between serum and peritoneal IL-18 levels in patients with endometriosis r = 0.794, P = 0.0001. All measurements were carried out at the same time by the Human IL-18 Immuno Assay ELISA kit (MBL Co. Ltd., Japan). The present study did not find evidence supporting the hypothesis that IL-18 levels are associated with infertility in women with minimal and mild endometriosis, although a positive correlation was detected in these women between peritoneal and serum levels of IL-18.
Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Liquide d'ascite
/
Endométriose
/
Infertilité féminine
Type d'étude:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limites du sujet:
Adult
/
Female
/
Humans
langue:
En
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
BIOLOGIA
/
MEDICINA
Année:
2009
Type:
Article