Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies
Mem. Inst. Oswaldo Cruz
;
104(6): 862-864, Sept. 2009. ilus
Article
Dans Anglais
| LILACS
| ID: lil-529555
ABSTRACT
The primary culture of intestinal epithelial cells from domestic cats is an efficient cellular model to study the enteric cycle of Toxoplasma gondii in a definitive host. The parasite-host cell ratio can be pointed out as a decisive factor that determines the intracellular fate of bradyzoites forms. The development of the syncytial-like forms of T. gondii was observed using the 120 bradyzoite-host cell ratio, resulting in similar forms described in in vivo systems. This alternative study potentially opens up the field for investigation into the molecular aspects of this interaction. This can contribute to the development of new strategies for intervention of a main route by which toxoplasmosis spreads.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Toxoplasma
/
Cellules épithéliales
/
Interactions hôte-parasite
/
Muqueuse intestinale
/
Étapes du cycle de vie
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2009
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Instituto Oswaldo Cruz-Fiocruz/BR
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