Cystatin C and renal function in pediatric kidney transplant recipients
Braz. j. med. biol. res
; 42(12): 1225-1229, Dec. 2009. tab
Article
Dans En
| LILACS
| ID: lil-532303
Responsable en Bibliothèque :
BR1.1
ABSTRACT
In clinical practice, the glomerular filtration rate (GFR) is often determined with serum creatinine. However, studies have shown cystatin C to be a better parameter for the diagnosis of impaired renal function. We compared GFR estimated by plasma cystatin C with GFR estimated by serum creatinine in a sample of 50 pediatric renal transplant recipients and 24 healthy children. The correlation between GFR estimated by serum creatinine and by cystatin C was significant (r = 0.75; P < 0.001, Persons correlation); however, in pediatric kidney transplant recipients, the GFR was 6.7 mL/min lower when determined using cystatin C rather than serum creatinine. Moreover, using GFR estimated by cystatin C we found that 42 percent of the pediatric kidney transplant recipients had an estimated GFR <60 mL·min-1·1.73 (m²)-1, whereas when GFR was estimated by the serum creatinine formula only 16 percent of the children had values below this cutoff point indicative of chronic kidney disease (P < 0.001). We conclude that, in pediatric kidney transplant recipients, estimation of GFR yields lower values when cystatin C is used rather than serum creatinine.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Transplantation rénale
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Créatinine
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Cystatine C
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Débit de filtration glomérulaire
Type d'étude:
Observational_studies
Limites du sujet:
Child
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Female
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Humans
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Male
langue:
En
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
BIOLOGIA
/
MEDICINA
Année:
2009
Type:
Article
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Project document