Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula
Mem. Inst. Oswaldo Cruz
; 104(7): 1035-1038, Nov. 2009. ilus, tab
Article
de En
| LILACS
| ID: lil-534172
Bibliothèque responsable:
BR1.1
ABSTRACT
The molluscicidal activity of Hammada scoparia leaf extracts and the principal alkaloids isolated from them (carnegine and N-methylisosalsoline) were tested against the mollusc gastropod, Galba truncatula, the intermediate host of Fasciola hepatica in Tunisia. The results indicated that the molluscicidal activity was correlated with the presence of alkaloids. A significant molluscicidal value, according to the World Health Organization, was found with the methanol extract (LC50 = 28.93 ppm). Further fractionation of the methanolic extract led to the isolation of two principal alkaloids carnegine and N-methylisosalsoline. These alkaloids are isoquinolines that have not previously been characterised for their molluscicidal activity. The N-methylisosalsoline possesses the highest molluscicidal activity (LC50 = 0.47 ìM against G. truncatula).
Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Plantes médicinales
/
Escargots
/
Extraits de plantes
/
Alcaloïdes
/
Isoquinoléines
/
Molluscicides
Limites du sujet:
Animals
langue:
En
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
MEDICINA TROPICAL
/
PARASITOLOGIA
Année:
2009
Type:
Article