Morphological analysis of the enamel organ in rats treated with fluoxetine
Clinics
;
65(1): 61-65, 2010. ilus
Article
Dans Anglais
| LILACS
| ID: lil-538608
ABSTRACT
Purpose:
Previous studies have evaluated the presence of serotonin in the dental epithelia and mesenchyme during odontogenesis, suggesting its participation in tooth development. Materials andmethods:
Here, we used fluoxetine, a selective serotonin re-uptake inhibitor, at a dose of 10 mg/kg, administered for 20 days during pregnancy in 12 Wistar rats to examine the influence of this drug on the development of the enamel organ of the upper first molars of rat fetuses at 17 days of intra-uterine life (i.u.l.), and at one, five and ten days postpartum. The pregnant rats were anesthetized with xylazine at 10 mg/kg and ketamine at 25 mg/kg. The fetuses were removed and beheaded; their jaws were removed, and the upper jaws were exposed. The tissues were fixed in Bouin's fixative, decalcified in 5 percent nitric acid for 4 - 12 h, conventionally processed for microscopy, and embedded in paraffin. Serial sections of approximately 5 mm were obtained and stained with hematoxylin and eosin, as well as periodic acid-Schiff. Results andconclusion:
Morphological analysis showed no structural changes in the experimental group compared to the controls, suggesting that, at the dose used, fluoxetine does not interfere with serotonin-mediated development of the enamel organ or the process of amelogenesis.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Fluoxétine
/
Inbiteurs sélectifs de la recapture de la sérotonine
/
Organe de l'émail
Limites du sujet:
Animaux
/
Grossesse
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2010
Type:
Article
Pays d'affiliation:
Brésil
/
Royaume-Uni
Institution/Pays d'affiliation:
Oral Medicine Unit/GB
/
Universidade Federal de Pernambuco/BR
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