Vasodilation increases pulse pressure variation, mimicking hypovolemic status in rabbits
Clinics
;
65(2): 189-194, 2010. ilus
Article
Dans Anglais
| LILACS
| ID: lil-539836
ABSTRACT
OBJECTIVE:
To test the hypothesis that pulse pressure respiratory variation (PPV) amplification, observed in hypovolemia, can also be observed during sodium nitroprusside (SNP)-induced vasodilation.INTRODUCTION:
PPV is largely used for early identification of cardiac responsiveness, especially when hypovolemia is suspected. PPV results from respiratory variation in transpulmonary blood flow and reflects the left ventricular preload variations during respiratory cycles. Any factor that decreases left ventricular preload can be associated with PPV amplification, as seen in hypovolemia.METHODS:
Ten anesthetized and mechanically ventilated rabbits underwent progressive hypotension by either controlled hemorrhage (Group 1) or intravenous SNP infusion (Group 2). Animals in Group 1 (n = 5) had graded hemorrhage induced at 10 percent steps until 50 percent of the total volume was bled. Mean arterial pressure (MAP) steps were registered and assumed as pressure targets to be reached in Group 2. Group 2 (n = 5) was subjected to a progressive SNP infusion to reach similar pressure targets as those defined in Group 1. Heart rate (HR), systolic pressure variation (SPV) and PPV were measured at each MAP step, and the values were compared between the groups.RESULTS:
SPV and PPV were similar between the experimental models in all steps (p > 0.16). SPV increased earlier in Group 2.CONCLUSION:
Both pharmacologic vasodilation and graded hemorrhage induced PPV amplification similar to that observed in hypovolemia, reinforcing the idea that amplified arterial pressure variation does not necessarily represent hypovolemic status but rather potential cardiovascular responsiveness to fluid infusion.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Choc hémorragique
/
Pression sanguine
/
Volume sanguin
/
Hypovolémie
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2010
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Hospital Israelita Albert Einstein/BR
/
Universidade da Região de Joinville/BR
/
Universidade de São Paulo/BR
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