Chemical composition and antiprotozoal activities of Colombian Lippia spp essential oils and their major components
Mem. Inst. Oswaldo Cruz
;
105(2): 184-190, Mar. 2010. tab
Article
Dans Anglais
| LILACS
| ID: lil-544635
ABSTRACT
The chemical composition and biological activities of 19 essential oils and seven of their major components were tested against free and intracellular forms of Leishmania chagasi and Trypanosoma cruzi parasites as well as Vero and THP-1 mammalian cell lines. The essential oils were obtained from different species of Lippia, a widely distributed genus of Colombian plants. They were extracted by microwave radiation-assisted hydro-distillation and characterised by GC-FID and GC-MS. The major components were geranial, neral, limonene, nerol, carvacrol, p-cymene, ã-terpinene, carvone and thymol. The essential oil of Lippia alba exhibited the highest activity against T. cruzi epimastigotes and intracellular amastigotes with an IC50 of 5.5 ìg/mL and 12.2 ìg/mL, respectively. The essential oil of Lippia origanoides had an IC50 of 4.4 ìg/mL in L. chagasi promastigotes and exhibited no toxicity in mammalian cells. Thymol (IC50 3.2 ± 0.4 ìg/mL) and S-carvone (IC50 6.1 ± 2.2 ìg/mL), two of the major components of the active essential oils, were active on intracellular amastigotes of T. cruziinfected Vero cells, with a selective index greater than 10. None of the essential oils or major components tested in this study was active on amastigotes of L. chagasi infected THP-1 cells.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Trypanosoma cruzi
/
Huiles végétales
/
Huile essentielle
/
Leishmania infantum
/
Lippia
/
Antiprotozoaires
Limites du sujet:
Animaux
Pays comme sujet:
Amérique du Sud
/
Colombie
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2010
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Colombie
Institution/Pays d'affiliation:
Universidad Industrial de Santander/CO
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