Thalamic nuclear abnormalities as a contributory factor in sudden cardiac deaths among patients with schizophrenia
Clinics
;
65(5): 539-546, 2010. ilus
Article
Dans Anglais
| LILACS
| ID: lil-548635
ABSTRACT
Patients with schizophrenia have a two- to three-fold increased risk of premature death as compared to patients without this disease. It has been established that patients with schizophrenia are at a high risk of developing cardiovascular disease. Moreover, an important issue that has not yet been explored is a possible existence of a "cerebral" focus that could trigger sudden cardiac death in patients with schizophrenia. Along these lines, several structural and functional alterations in the thalamic complex are evident in patients with schizophrenia and have been correlated with the symptoms manifested by these patients. With regard to abnormalities on the cellular and molecular level, previous studies have shown that schizophrenic patients have fewer neuronal projections from the thalamus to the prefrontal cortex as well as a reduced number of neurons, a reduced volume of either the entire thalamus or its subnuclei, and abnormal glutamate signaling. According to the glutamate hypothesis of schizophrenia, hypofunctional corticostriatal and striatothalamic projections are directly involved in the pathophysiology of the disease. Animal and post-mortem studies have provided a large amount of evidence that links the sudden unexpected death in epilepsy (SUDEP) that occurs in patients with schizophrenia and epilepsy to thalamic changes. Based on the results of these prior studies, it is clear that further research regarding the relationship between the thalamus and sudden cardiac death is of vital importance.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Schizophrénie
/
Noyaux du thalamus
/
Mort subite cardiaque
Type d'étude:
Etude d'étiologie
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2010
Type:
Article
Pays d'affiliation:
Brésil
/
Allemagne
Institution/Pays d'affiliation:
Universidade Federal de São Paulo/BR
/
Universidade Presbiteriana Mackenzie/BR
/
Universidade de São Paulo/BR
/
University of Goettingen/DE
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