Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
Braz. oral res
;
24(2): 170-176, Apr.-June 2010. ilus
Article
Dans Anglais
| LILACS
| ID: lil-553903
ABSTRACT
Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tibia
/
Régénération osseuse
/
Consolidation de fracture
/
Hypertension artérielle
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. oral res
Thème du journal:
Dentisterie
Année:
2010
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Guarulhos University/BR
/
Nove de Julho University/BR
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