The effect of Helicobacter pylori eradication on macrophage migration inhibitory factor, C-reactive protein and fetuin-a levels
Clinics
;
65(8): 799-802, June 2010. graf, tab
Article
Dans Anglais
| LILACS
| ID: lil-557007
ABSTRACT
OBJECTIVES:
To determine the effect of Helicobacter pylori (H. pylori) eradication on blood levels of high-sensitivity C-reactive protein (hs-CRP), macrophage migration inhibitory factor and fetuin-A in patients with dyspepsia who are concurrently infected with H. pylori.METHODS:
H.pylori infection was diagnosed based on the 14C urea breath test (UBT) and histology. Lansoprazole 30 mg twice daily, amoxicillin 1 g twice daily, and clarithromycin 500 mg twice daily were given to all infected patients for 14 days; 14C UBT was then re-measured. In 30 subjects, migration inhibitory factor, fetuin-A and hs-CRP levels were examined before and after the eradication of H. pylori infection and compared to levels in 30 healthy subjects who tested negative for H. pylori infection.RESULTS:
Age and sex distribution were comparable between patients and controls. Migration inhibitory factor and hs-CRP levels were higher, and fetuin-A levels were lower, in H. pylori-infected patients (p<0.05). Following eradication of H. pylori, migration inhibitory factor and hs-CRP levels were significantly decreased, whereas fetuin-A levels were increased. However, eradication of the organism did not change lipid levels (p>0.05).CONCLUSION:
These findings suggest that H. pylori eradication reduces the levels of pro-inflammatory cytokines such as migration inhibitory factor and hs-CRP and also results in a significant increase in anti-inflammatory markers such as fetuin-A.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Protéine C-réactive
/
Protéines du sang
/
Helicobacter pylori
/
Infections à Helicobacter
/
Facteurs inhibiteurs de la migration des macrophages
/
Dyspepsie
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte
/
Humains
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2010
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Izmir Bozyaka Training and Research Hospital/TR
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