Brain plasticity, signal transduction and epigenesis: a missing link revealed
ARBS annu. rev. biomed. sci
;
11(n.esp): T114-T122, 20090000. ilus
Article
Dans Anglais
| LILACS
| ID: lil-560454
ABSTRACT
It has been long thought that the brain reorganizes itself in response to environmental needs. Sensory experiences coded in action potentials are the mean by which information on the surroundings is introduced into neuronal networks. The information approaching the brain in the form of electrochemical codes must then be translated in biochemical, epigenetic and genetic ones. Only until recently we have begun understanding the underpinning of such informational transformations and how this process is expressed as neuronal plastic responses. Central for our comprehension of this matter is the finding that signals transduction cascades can modify gene expression by remodeling the chromatin through epigenetic mechanisms. Hence, chromatin remodeling seems to be the process by which experiences are imprinted.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Transduction du signal
/
Expression des gènes
/
Épigenèse génétique
/
Plasticité neuronale
langue:
Anglais
Texte intégral:
ARBS annu. rev. biomed. sci
Thème du journal:
Biologie
Année:
2009
Type:
Article
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Instituto Nacional de Pediatría/MX
/
Universidad Michoacana de San Nicolás de Hidalgo/MX
/
Universidad Nacional Autónoma de México/MX
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