Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
Clinics
;
65(10): 1037-1042, 2010. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-565991
ABSTRACT
INTRODUCTION:
We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae).METHODS:
We used elevated plus maze, spontaneous motor activity and ketamine-induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n-decanal (70.1 percent) and alpha-pinene (12.4 percent) constituted the major components.RESULTS:
In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25-200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine-induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Plantes médicinales
/
Sommeil
/
Anxiolytiques
/
Huiles végétales
/
Apprentissage du labyrinthe
/
Hypnotiques et sédatifs
/
Activité motrice
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2010
Type:
Article
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