Overlooked post-translational modifications of proteins in Plasmodium falciparum: N- and O-glycosylation - A Review
Mem. Inst. Oswaldo Cruz
;
105(8): 949-956, Dec. 2010. graf, tab
Article
Dans Anglais
| LILACS
| ID: lil-570663
ABSTRACT
Human malignant malaria is caused by Plasmodium falciparum and accounts for almost 900,000 deaths per year, the majority of which are children and pregnant women in developing countries. There has been significant effort to understand the biology of P. falciparum and its interactions with the host. However, these studies are hindered because several aspects of parasite biology remain controversial, such as N- and O-glycosylation. This review describes work that has been done to elucidate protein glycosylation in P. falciparum and it focuses on describing biochemical evidence for N- and O-glycosylation. Although there has been significant work in this field, these aspects of parasite biochemistry need to be explored further.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Plasmodium falciparum
/
Protéines de protozoaire
/
Maturation post-traductionnelle des protéines
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2010
Type:
Article
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