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Growth inhibition and morphological alterations of Trichophyton rubrum induced by essential oil from Cymbopogon winterianus Jowitt ex Bor
Pereira, Fillipe de Oliveira; Wanderley, Paulo Alves; Viana, Fernando Antônio Cavalcanti; Lima, Rita Baltazar de; Sousa, Frederico Barbosa de; Lima, Edeltrudes de Oliveira.
  • Pereira, Fillipe de Oliveira; Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Laboratório de Micologia. BR
  • Wanderley, Paulo Alves; Universidade Federal da Paraíba. Centro de Formação de Tecnólogos. Departamento de Agricultura. BR
  • Viana, Fernando Antônio Cavalcanti; Universidade Federal da Paraíba. Centro de Ciências da Saúde. Laboratório de Tecnologia Farmacêutica. Horto de Plantas Medicinais. BR
  • Lima, Rita Baltazar de; Universidade Federal da Paraíba. Centro de Ciências Exatas e da Natureza. Departamento de Sistemática e Ecologia. Laboratório de Botânica. BR
  • Sousa, Frederico Barbosa de; Universidade Federal da Paraíba. Centro de Ciências da Saúde. Laboratório de Microscopia e Imagem Biológica. BR
  • Lima, Edeltrudes de Oliveira; Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Laboratório de Micologia. BR
Braz. j. microbiol ; 42(1): 233-242, Jan.-Mar. 2011. ilus, tab
Article Dans Anglais | LILACS | ID: lil-571394
ABSTRACT
Trichophyton rubrum is one of the most common fungi causer of dermatophytosis, mycosis that affect humans and animals around the world. Researches aiming new products with antifungal activity become necessary to overcome difficulties on treatment of these infections. Accordingly, this study aimed to investigate the antifungal activity of essential oil from Cymbopogon winterianus against the dermatophyte T. rubrum. The antifungal screening was performed by solid medium diffusion method with 16 T. rubrum strains, minimum inhibitory concentration (MIC) and minimum fungicide concentration (MFC) were determined using the microdilution method. The effects on mycelial dry weight and morphology were also observed. Screening showed essential oil in natura inhibited all the tested strains, with inhibition zones between 24-28 mm diameter. MIC50 and MIC90 values of the essential oil were 312 µg/mL for nearly all the essayed strains (93.75 percent) while the MFC50 and MFC90 values were about eight times higher than MIC for all tested strains. All tested essential oil concentrations managed to inhibit strongly the mycelium development. Main morphological changes on the fungal strains observed under light microscopy, which were provided by the essential oil include loss of conidiation, alterations concerning form and pigmentation of hyphae. In the oil presence, colonies showed folds, cream color and slightly darker than the control, pigment production was absent on the reverse and with evident folds. It is concluded that C. winterianus essential oil showed activity against T. rubrum. Therefore, it could be known as potential antifungal compound especially for protection against dermatophytosis.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Spores fongiques / Trichophyton / Huile essentielle / Mycelium / Cymbopogon / Mycoses cutanées / Arthrodermataceae / Antifongiques Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Braz. j. microbiol Thème du journal: Microbiologie Année: 2011 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal da Paraíba/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Spores fongiques / Trichophyton / Huile essentielle / Mycelium / Cymbopogon / Mycoses cutanées / Arthrodermataceae / Antifongiques Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Braz. j. microbiol Thème du journal: Microbiologie Année: 2011 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal da Paraíba/BR