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El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía / Tumor necrosis factor-alpha and interleukin-6 levels among patients suffering a bile duct injury during cholecystectomy
MIRANDA-DÍAZ, ALEJANDRA G; HERMOSILLO-SANDOVAL, JOSÉ M; HUERTA-ROSAS, GONZALO; LÓPEZ-GUILLÉN, GERMÁN G; CARDONA MUÑOZ, ERNESTO G; GARCÍA-IGLESIAS, TRINIDAD; PACHECO-MOISÉS, FERMÍN; ALATORRE-CARRANZA, MARÍA DEL P.
  • MIRANDA-DÍAZ, ALEJANDRA G; Universidad de Guadalajara. Centro Universitario de Ciencias de la salud. Departamento de Clínicas Quirúrgicas. Guadalajara. MX
  • HERMOSILLO-SANDOVAL, JOSÉ M; instituto Mexicano del seguro social. Hospital de especialidades del centro Médico Nacional de occidente. Guadalajara. MX
  • HUERTA-ROSAS, GONZALO; instituto Mexicano del seguro social. Hospital de especialidades del centro Médico Nacional de occidente. Guadalajara. MX
  • LÓPEZ-GUILLÉN, GERMÁN G; instituto Mexicano del seguro social. Hospital de especialidades del centro Médico Nacional de occidente. Guadalajara. MX
  • CARDONA MUÑOZ, ERNESTO G; Universidad de Guadalajara. Centro Universitario de ciencias de la salud. MX
  • GARCÍA-IGLESIAS, TRINIDAD; Universidad de Guadalajara. Centro Universitario de ciencias de la salud. MX
  • PACHECO-MOISÉS, FERMÍN; Universidad de Guadalajara. Centro Universitario de ciencias exactas e ingeniería. MX
  • ALATORRE-CARRANZA, MARÍA DEL P; Universidad de Guadalajara. Centro Universitario de ciencias de la salud. MX
Rev. méd. Chile ; 138(10): 1259-1263, oct. 2010. graf
Article Dans Espagnol | LILACS | ID: lil-572937
ABSTRACT

Background:

During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL6) to phagocyte toxic products

Aim:

To measure serum levels of TNF-α and IL-6 among patients that suffered a bile duct injury after a cholecystectomy. Patients and

Methods:

Serum levels of TNF-α and IL-6 were measured prior to the bile-enteric derivation and after one year of follow up, in 31 patients that had a complete bile duct obstruction after open or laparoscopic cholecystectomy and in 5 healthy controls.

Results:

At baseline TNF-α levels in healthy subjects and patients with bile duct injury were 0 and 43.9 ± 2.9 ng/mL, respectively (p < 0.01). At one year of follow up, TNF-á became undetectable among patients. At baseline, the values for IL-6 among healthy controls and patients were 3.0 ± 2.0 and 72.0 ± 94.7 pg/mL respectively, (p < 0,004). After one year of follow up, IL-6 levels decreased to 6.4 ± 0.3 pg/mL among patients.

Conclusions:

TNF-α and IL-6 levels were elevated before bile-enteric derivation among patients with bile duct injury and became normal one year later.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Conduits biliaires / Cholestase / Facteur de nécrose tumorale alpha / Cholécystectomie laparoscopique / Cellules de Küpffer Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Femelle / Humains / Mâle langue: Espagnol Texte intégral: Rev. méd. Chile Thème du journal: Médicament Année: 2010 Type: Article / descriptif de projet Pays d'affiliation: Mexique Institution/Pays d'affiliation: Universidad de Guadalajara/MX / instituto Mexicano del seguro social/MX

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Conduits biliaires / Cholestase / Facteur de nécrose tumorale alpha / Cholécystectomie laparoscopique / Cellules de Küpffer Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Femelle / Humains / Mâle langue: Espagnol Texte intégral: Rev. méd. Chile Thème du journal: Médicament Année: 2010 Type: Article / descriptif de projet Pays d'affiliation: Mexique Institution/Pays d'affiliation: Universidad de Guadalajara/MX / instituto Mexicano del seguro social/MX