Deficiencia de vitamina D: ¿Factor de riesgo de síndrome metabólico? / Association between vitamin D deficiency and metabolic syndrome
Rev. méd. Chile
;
138(10): 1312-1318, oct. 2010. ilus
Article
Dans Espagnol
| LILACS
| ID: lil-572946
ABSTRACT
Vitamin D has an essential role in calcium metabolism and bone health. Vitamin D3 or cholecalciferol is synthesized from 7-dehydrocholesterol or provitamin D3, by sunlight ultraviolet radiation to the skin. 7-dehydrocholesterol is subsequently hydroxylated in the liver and then in the kidney to produce 1,25-(OH)2D3, the active metabolite that binds to specific receptors (VDR) in target tissues, mainly bone and intestine. Other tissues, such as the immune and cardiovascular system, have also VDR. Vitamin D deficiency can induce rickets in children and osteomalacia and osteoporosis in adults. A possible inverse association between vitamin D levels and the prevalence of metabolic syndrome has been proposed. Vitamin D deficiency increases the risk of type 1 diabetes, insulin resistance, and hypertension, key components of this syndrome. However, other studies have not confirmed this association. Further clinical and experimental studies are needed to ascertain the role of vitamin D in metabolic syndrome.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Carence en vitamine D
/
Syndrome métabolique X
Type d'étude:
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2010
Type:
Article
Pays d'affiliation:
Venezuela
Institution/Pays d'affiliation:
Universidad de Carabobo/VE
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