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Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats
Fernandes, Leandro Araújo; Martins, Thiago Marchi; Almeida, Juliano Milanezi De; Nagata, Maria José Hitomi; Theodoro, Leticia Helena; Garcia, Valdir Gouveia; Bosco, Alvaro Francisco.
  • Fernandes, Leandro Araújo; São Paulo State Universit. Araçatuba Dental School. Department of Surgery and Integrated Clinic. Araçatuba. BR
  • Martins, Thiago Marchi; São Paulo State Universit. Araçatuba Dental School. Department of Surgery and Integrated Clinic. Araçatuba. BR
  • Almeida, Juliano Milanezi De; São Paulo State Universit. Araçatuba Dental School. Department of Surgery and Integrated Clinic. Araçatuba. BR
  • Nagata, Maria José Hitomi; São Paulo State Universit. Araçatuba Dental School. Department of Surgery and Integrated Clinic. Araçatuba. BR
  • Theodoro, Leticia Helena; University Center of Educational Foundation of Barretos. Barretos Dental School. Department of Periodontics. Barretos. BR
  • Garcia, Valdir Gouveia; University Center of Educational Foundation of Barretos. Barretos Dental School. Department of Periodontics. Barretos. BR
  • Bosco, Alvaro Francisco; University Center of Educational Foundation of Barretos. Barretos Dental School. Department of Periodontics. Barretos. BR
J. appl. oral sci ; 18(6): 635-640, Nov.-Dec. 2010. ilus, tab
Article Dans Anglais | LILACS | ID: lil-573736
ABSTRACT

OBJECTIVE:

The aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. MATERIAL AND

METHODS:

In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05).

RESULTS:

In the histometric analysis, at 7, 15 and 30 days, Group T (0.72±0.05 mm², 0.57±0.14 mm², 0.62±0.07 mm²), showed less bone loss (p<0.05) than Group C (1.35±0.25 mm²; 1.40±0.31 mm²; 1.29±0.27 mm²), respectively.

CONCLUSIONS:

Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Parodontite / Tétracycline / Antibactériens Type d'étude: Études d'évaluation Limites du sujet: Animaux langue: Anglais Texte intégral: J. appl. oral sci Thème du journal: Dentisterie Année: 2010 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: São Paulo State Universit/BR / University Center of Educational Foundation of Barretos/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Parodontite / Tétracycline / Antibactériens Type d'étude: Études d'évaluation Limites du sujet: Animaux langue: Anglais Texte intégral: J. appl. oral sci Thème du journal: Dentisterie Année: 2010 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: São Paulo State Universit/BR / University Center of Educational Foundation of Barretos/BR