Predicción de sobrevida del injerto a corto y largo plazo mediante el uso de índices gamagráficos en receptores de trasplante renal / Prediction of short and long term graft survival by 99mTc-MAG3 scintigraphy after renal transplantation
Rev. med. nucl. Alasbimn j
;
12(49)July 2010. ilus, tab, graf
Article
Dans Espagnol
| LILACS
| ID: lil-580221
ABSTRACT
Background:
99Tcm-MAG3 is a non-invasive method for the evaluation of renal transplants, giving information about allograft function and short- and long-term allograft survival. However, few studies have validated this observation. Objetive To determine the predictive power of different scintigraphic parameters on graft survival at 6 -12 months after renal transplantation.Methods:
Between 1996-2007, receptors with varying degrees of kidney dysfunction were studied with 99mTc-MAG3 scintigraphy within 14 days after transplantation. Tubular injury score (TISS) ranging I-VI according to severity and renal extraction index (R20/3) were calculated. Survival analysis and Cox regression were used for analysis.Results:
Three-hundred and four renograms were performed in 146 allografts (143 receptors, mean age 38.9 +/- 17 years, 81.5 percent from cadaveric donor). Mean follow-up time was 44 months. There was graft loss (GL) in 32 percent renal trasplants. According to severity range, graft survival at 6 and 12 months was TISS I-II 85.23 percent and 81.17 percent; TISS III-IV 82.43 percent and 80.56 percent, and TISS V-VI 32 percent and 2.,43 percent respectively. TISS score of V-VI score was an independent predictor for GL (HR = 6.3 CI 95 percent 2.913; p<0.0001). R20/3 index was not a good predictor of GL.Conclusions:
TISS score was an independent predictor of short- and long-term allograft survival using 99mTc-MAG3 scintigraphy performed early after kidney transplantation in patients with suspected patients renal dysfunction. TISS V-VI had a greater discriminatory power. R20/3 index individually did not present a good prognostic performance.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Transplantation rénale
/
Survie du greffon
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Rev. med. nucl. Alasbimn j
Thème du journal:
Médecine nucléaire
Année:
2010
Type:
Article
Pays d'affiliation:
Colombie
Institution/Pays d'affiliation:
Instituto de investigaciones Fundación Clínica Valle del Lili/CO
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