Correlation of meta 1 expression with culture stage, cell morphology and infectivity in Leishmania (Leishmania) amazonensis promastigotes
Mem. Inst. Oswaldo Cruz
;
106(2): 190-193, Mar. 2011. graf, tab
Article
Dans Anglais
| LILACS
| ID: lil-583944
ABSTRACT
The parasitic protozoan Leishmania (Leishmania) amazonensis alternates between mammalian and insect hosts. In the insect host, the parasites proliferate as procyclic promastigotes andthen differentiate into metacyclic infective forms. The meta 1 gene is preferentially expressed during metacyclogenesis. Meta 1 expression profile determination along parasite growth curves revealed that the meta 1 mRNA level peaked at the early stationary phase then decreased to an intermediate level. No correlation was observed between meta 1 expression and infectivity. Conversely, infectivity correlated with the increase of apoptotic cells in the late stationary phase.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Leishmania mexicana
/
ARN messager
/
ARN des protozoaires
/
Gènes de protozoaire
/
Analyse de profil d'expression de gènes
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2011
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Instituto Butantan/BR
/
Universidade de São Paulo/BR
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