Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients
Mem. Inst. Oswaldo Cruz
;
106(2): 220-226, Mar. 2011. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-583949
ABSTRACT
The CTLA-4 protein is expressed in activated T cells and plays an essential role in the immune response through its regulatory effect on T cell activation. Polymorphisms of the CTLA-4 gene have been correlated with autoimmune, neoplastic and infectious illnesses. This work aimed to verify possible associations between single nucleotide polymorphisms (SNPs) in CTLA-4, -318C/T in the promoter and +49A/G in exon 1 and paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis. For this purpose, 66 chronic form PCM patients and 76 healthy controls had their allele, genotype and haplotype frequencies determined. The genetic admixture structure of the patients and controls was evaluated to eliminate ancestral bias. The comparison of frequencies indicated no significant differences between patients and controls that could link the SNPs to PCM. Groups were admixture matched with no difference observed in population ancestry inference, indicating that the absence of association between CTLA-4 polymorphisms and PCM could not be attributed to ancestral bias. This study showed that there was no association between the CTLA-4 SNPs -318 and +49 and the resistance or susceptibility to PCM.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Blastomycose sud-américaine
/
Antigènes CD
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2011
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Católica de Brasília/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Federal de Minas Gerais/BR
/
Universidade de Brasília/BR
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