Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
J. appl. oral sci
;
19(3): 260-268, May-June 2011. ilus, graf, tab
Article
Dans Anglais
| LILACS
| ID: lil-588133
ABSTRACT
The pathogenesis of alveolitis is not well known and therefore experimental situations that mimic some features of this disease should be developed. OBJECTIVE:
In this study, the evolution of the experimentally induced infection in rat sockets is characterized, which leads to clinical signs of suppurative alveolitis with remarkable wound healing disturbs. MATERIAL ANDMETHODS:
Non-infected (Group I) and experimentally infected sockets in Rattus novergicus (Group II) were histometrically evaluated regarding the kinetics of alveolar healing. In addition, the characterization of the present bacteria in inoculation material and the serum levels of C-reactive protein (CRP) were performed. The detected species were Capnocytophaga ochracea, Fusobacterium nucleatum ss nucleatum, Prevotella melaninogenica, Streptococcus anginosus, Treponema socranskii and Streptococcus sanguis.RESULTS:
All experimentally infected rats developed suppurative alveolitis, showing higher levels of CRP in comparison to those non-infected ones. Furthermore, infected rats presented a significant delayed wound healing as measured by the histometric analysis (higher persistent polymorphonuclear infiltrate and lower density of newly formed bone).CONCLUSION:
These findings indicate that rat sockets with experimentally induced infection produced higher levels of serum CRP, showing the potential of disseminated infection and a disturb in the alveolar repair process in an interesting experimental model for alveolitis studies.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Extraction dentaire
/
Cicatrisation de plaie
/
Alvéole dentaire
/
Alvéolite
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. appl. oral sci
Thème du journal:
Dentisterie
Année:
2011
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Guarulhos University/BR
/
São Lucas School/BR
/
University of São Paulo/BR
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