Upper airway collapsibility evaluated by a negative expiratory pressure test in severe obstructive sleep apnea
Clinics
;
66(4): 567-572, 2011. ilus, graf, tab
Article
Dans Anglais
| LILACS
| ID: lil-588905
ABSTRACT
OBJECTIVES:
To investigate the usefulness of measuring upper airway collapsibility with a negative expiratory pressure application as a screening test for severe obstructive sleep apnea (OSA).INTRODUCTION:
OSA is a risk factor for cardiovascular disease, and it may have serious consequences. Its recognition may have important implications during the perioperative period. Increased upper airway collapsibility is one of the main determinants of OSA, and its evaluation could be useful for identifying this condition.METHODS:
Severe OSA and normal subjects (24 in each group) were matched by body mass index and referred to our sleep laboratory. The subjects were enrolled in an overnight sleep study, and a diurnal negative expiratory pressure test was performed. Flow drop (DV) and expiratory volume were measured in the first 0.2 s (V02) of the negative expiratory pressure test.RESULTS:
DV ( percent) and V02 ( percent) values were statistically different between normal and OSA subjects. OSA patients showed a greater decrease in flow than normal subjects. In addition, severely OSA patients exhaled during the first 0.2 s of the negative expiratory pressure application was an average of only 11.2 percent of the inspired volume compared to 34.2 percent for the normal subjects. Analysis of the receiver operating characteristics showed that V02 ( percent) and DV ( percent) could accurately identify severe OSA in subjects with sensitivities of 95.8 percent and 91.7 percent, respectively, and specificities of 95.8 percent and 91.7 percent, respectively.CONCLUSIONS:
V02 ( percent) and DV ( percent) are highly accurate parameters for detecting severe OSA. The pharyngeal collapsibility measurement, which uses negative expiratory pressure during wakefulness, is predictive of collapsibility during sleep.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tests de la fonction respiratoire
/
Syndrome d'apnées obstructives du sommeil
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Obstruction des voies aériennes
Type d'étude:
Étude observationnelle
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Étude pronostique
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Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2011
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
/
Italie
Institution/Pays d'affiliation:
National Research Council of Italy/IT
/
Universidade Nove de Julho/BR
/
University of Messina A.O.U. ''G. Martino''/IT
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