Langerhans cells in periodontal disease of HIV- and HIV+ patients undergoing highly active antiretroviral therapy
Braz. oral res
;
25(3): 255-260, May-June 2011. tab
Article
Dans Anglais
| LILACS
| ID: lil-590044
ABSTRACT
The aim of this study was to assess and compare quantitatively the presence of S100+ Langerhans cells (LC) by immunochemistry techniques in HIV+ and HIV- gingivitis and periodontitis subjects. Additionally, it aimed to evaluate the correlation among densities of these cells with CD4+ and CD8+ T cells, and viral load levels in HIV+ subjects, all using Highly Active Antiretroviral Therapy (HAART). The samples were allocated into four groups 1) 15 subjects with moderate chronic periodontitis (MCP), HIV+; 2) 15 subjects with MCP, HIV-; 3) 10 subjects with gingivitis (G), HIV+; and 4) 10 subjects with G, HIV-. The S100+ cells were assessed in the pocket epithelium, gingival epithelium, and lamina propria. A statistically significant increase of total S100+ cells in HIV+ periodontitis subjects was observed in relation to HIV- periodontitis subjects. No increase of S100+ cells with increased inflammation was observed. No statistically significant correlation among S100+ cells and blood levels of CD4, CD8, and viral load was observed. In conclusion, the use of HAART can aid in achieving viral loads, and it is suggested that it may prevent the destruction of the LC.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Parodontite
/
Infections à VIH
/
Cellules de Langerhans
/
Thérapie antirétrovirale hautement active
/
Gingivite
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. oral res
Thème du journal:
Dentisterie
Année:
2011
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Federal University of Minas Gerais/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS