The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
Clinics
;
66(5): 743-746, 2011. tab
Article
Dans Anglais
| LILACS
| ID: lil-593834
ABSTRACT
OBJECTIVE:
To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration.METHOD:
The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration.RESULT:
The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the age-related macular degeneration patient group than in the control group (p<0.05). The superoxide dismutase activity in the serum was significantly lower in the age-related macular degeneration patient group than in the control group (p<0.05). The levels of vitamin C and glutathione and the activity of glutathione peroxidase in the serum were unchanged between groups (p>0.05).CONCLUSION:
The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Superoxide dismutase
/
Peroxydation lipidique
/
Stress oxydatif
/
Néovascularisation choroïdienne
/
Glutathione peroxidase
/
Dégénérescence maculaire
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2011
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Ankara Numune Education and Research Hospital/TR
/
Duatepe Government Hospita/TR
/
Etimesgut Public Health Laboratory/TR
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