CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity
Biocell
;
34(2): 91-94, Aug. 2010. ilus, graf
Article
Dans Anglais
| LILACS
| ID: lil-595038
ABSTRACT
CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Leucémie myéloïde
/
Mouvement cellulaire
/
Prolongements cytoplasmiques
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Biocell
Thème du journal:
Clulas
Année:
2010
Type:
Article
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
China Medical University/CN
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