Biochemical recurrence after radical prostatectomy: is the disease or the surgeon to blame?
Int. braz. j. urol
;
37(3): 328-335, May-June 2011. tab
Article
Dans Anglais
| LILACS
| ID: lil-596007
ABSTRACT
PURPOSE:
The PSA recurrence develops in 27 to 53 percent within ten years after radical prostatectomy (RP). We investigated the factors (disease grade and stage or the surgeon's expertise,) more likely to influence biochemical recurrence in men post-radical prostatectomy for organ-confined prostate cancer by different surgeons in the same institution. MATERIALS ANDMETHODS:
A total of 510 patients that underwent radical prostatectomy were investigated retrospectively. Biochemical recurrence was defined as detection of a PSA level of > 0.20 ng/mL by two subsequent measurements. The causes, which are likely to influence the development of PSA recurrence, were separated into two groups as those related to the disease and those related to the surgical technique.RESULTS:
Biochemical recurrence was detected in 23.5 percent (120 cases) of 510 cases. The parameters most likely to influence biochemical recurrence were PSA level (p < 0.0001), T stage (p < 0.0001), the presence of extracapsular invasion prostate (p < 0.0001), Gleason scores (p = 0.042, p < 0.0001) and the presence of biopsy with perineural invasion (p = 0.03). The only surgical factor that demonstrated relevance was inadvertent capsular incision during the surgery that influenced the PSA recurrence (p < 0.0001).CONCLUSION:
The PSA recurrence was detected in 21.6 percent of patients who had been treated with radical prostatectomy within 5 years, which indicates that the parameters related to the disease and the patient have a pivotal role in the PSA recurrence.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Prostatectomie
/
Tumeurs de la prostate
/
Urologie
/
Antigène spécifique de la prostate
/
Récidive tumorale locale
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Int. braz. j. urol
Thème du journal:
Urologie
Année:
2011
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Ege University Medical Faculty/TR
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