Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank
Rev. bras. hematol. hemoter
;
33(2): 110-114, 2011. tab
Article
Dans Anglais
| LILACS
| ID: lil-596299
ABSTRACT
BACKGROUND:
The study of platelet aggregation is essential to assess in vitro platelet function by different platelet activation pathways.OBJECTIVE:
To assess aggregation and biochemical parameters of random platelet concentrates produced at the Fundação HEMOAM using the quality control tests defined by law.METHODS:
Whole blood samples from 80 donors and the respective platelet concentrate units were tested. Platelet concentrates were tested (platelet count, aggregation and pH) on days 1, 3 and 5 of storage. Additionally a leukocyte count was done only on day 1 and microbiological tests on day 5 of storage. Collagen and adenosine diphosphate were used as inducing agonists for platelet aggregation testing.RESULTS:
Donor whole blood had normal aggregation (aggregation with adenosine diphosphate = 67 percent and with collagen = 78 percent). The median aggregation in platelet concentrates with adenosine diphosphate was low throughout storage (18 percent on day 1, 7 percent on day 3 and 6 percent on day 5) and the median aggregation with collagen was normal only on day 1 and low thereafter (54.4 percent on day 1, 20.5 percent on day 3 and 9 percent on day 5).CONCLUSION:
Although the results were within the norms required by law, platelet concentrates had low aggregation rates. We suggest the inclusion of a functional assessment test for the quality control of platelet concentrates for a more effective response to platelet replacement therapy.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Contrôle de qualité
/
Banques de sang
/
Agrégation plaquettaire
/
Transfusion de composants du sang
/
Hémostase
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Rev. bras. hematol. hemoter
Thème du journal:
Hématologie
Année:
2011
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Centro Universitário do Norte/BR
/
Fundação de Hematologia e Hemoterapia do Amazonas/BR
/
Fundação de Hematologia e Hemoterapia/BR
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