Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension
Braz. j. med. biol. res
;
44(9): 871-876, Sept. 2011. ilus
Article
Dans Anglais
| LILACS
| ID: lil-599659
ABSTRACT
Neurogenic hypertension has been the subject of extensive research worldwide. This review is based on the premise that some forms of neurogenic hypertension are caused in part by the formation of angiotensin-II (Ang-II)-induced reactive oxygen species along the subfornical organ-paraventricular nucleus of the hypothalamus-rostral ventrolateral medulla pathway (SFO-PVN-RVLM pathway). We will discuss the recent contribution of our laboratory and others regarding the mechanisms by which neurons in the SFO (an important circumventricular organ) are activated by Ang-II, how the SFO communicates with two other important areas involved in sympathetic activity regulation (PVN and RVLM) and how Ang-II-induced reactive oxygen species participate along the SFO-PVN-RVLM pathway in the pathogenesis of neurogenic hypertension.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Noyau paraventriculaire de l'hypothalamus
/
Organe subfornical
/
Angiotensine-II
/
Moelle allongée
/
Espèces réactives de l'oxygène
/
Hypertension artérielle
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2011
Type:
Article
/
Congrès et conférence
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal da Paraíba/BR
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