Triorganotin as a compound with potential reproductive toxicity in mammals
Braz. j. med. biol. res
;
44(9): 958-965, Sept. 2011. ilus
Article
Dans Anglais
| LILACS
| ID: lil-599669
ABSTRACT
Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Composés organiques de l'étain
/
Trialkyl-stannanes
/
Système génital
/
Mammifères
Limites du sujet:
Animaux
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2011
Type:
Article
/
Congrès et conférence
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal do Espírito Santo/BR
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