Titers of ABO antibodies in group O blood donors
Rev. bras. hematol. hemoter
;
33(4): 259-262, 2011. tab
Article
Dans Anglais
| LILACS
| ID: lil-601002
ABSTRACT
BACKGROUND:
Plasma components of group O blood donations are rarely submitted to ABO antibody titrations even though it is well known that passively acquired antibodies may destroy the recipient's own red cells and tissue grafts.OBJECTIVE:
Thus, group O donations stratified by gender and age were randomly titrated to identify the best source of products for apheresis and exsanguinous transfusion.METHODS:
Samples from 603 blood donors were tested by ABO antibody titration using the conventional tube technique at room temperature. ABO antibody levels higher than 64 were considered high. After correction for gender, statistical analyses were performed using the Fisher exact and Kruskal-Wallis tests.RESULTS:
Most donors in the blood bank were male (65.7 percent). ABO antibody titers ranged from 1 to 2048. The estimations of prevalence for the titers were anti-A,B < 128 = 86.9 percent and > 128 = 2.16 percent; Anti-A > 128 = 9.29 percent and anti-B > 128 = 4.81 percent. Low mean titers for both anti-A and anti-B antibodies were found in over 50-year-old men (p-value = 0.040). High anti-B antibody levels were found in young women (p-value = 0.002).CONCLUSION:
This study confirms that over 50-year-old O group men should be selected as blood donors in non-identical ABO transfusion situations. Also, titration of ABO antibodies in blood banks will increase safety in non-identical ABO transfusions.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Donneurs de sang
/
Antigènes de groupe sanguin
/
Plaquettes
/
Transfusion sanguine
/
Système ABO de groupes sanguins
/
Tests d'agglutination
/
Titrimétrie
/
Charge virale
/
Agglutinines
/
Réaction antigène-anticorps
Type d'étude:
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Rev. bras. hematol. hemoter
Thème du journal:
Hématologie
Année:
2011
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Banco de Sangue de São Paulo/BR
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