Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
Mem. Inst. Oswaldo Cruz
;
106(6): 759-762, Sept. 2011. ilus
Article
Dans Anglais
| LILACS
| ID: lil-602062
ABSTRACT
The human T-lymphotropic virus type-1 (HTLV-1) is the cause of adult T cell leukaemias/lymphoma. Because thymic epithelial cells (TEC) express recently defined receptors for the virus, it seemed conceivable that these cells might be a target for HTLV-1 infection. We developed an in vitro co-culture system comprising HTLV-1+-infected T cells and human TECs. Infected T cells did adhere to TECs and, after 24 h, the viral proteins gp46 and p19 were observed in TECs. After incubating TECs with culture supernatants from HTLV-1+-infected T cells, we detected gp46 on TEC membranes and the HTLV-1 tax gene integrated in the TEC genome. In conclusion, the human thymic epithelium can be infected in vitro by HTLV-1, not only via cell-cell contact, but also via exposure to virus-containing medium.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Thymus (glande)
/
Lymphocytes T
/
Virus T-lymphotrope humain de type 1
/
Cellules épithéliales
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2011
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fiocruz/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS