Contractile reactivity of the perfused mesenteric vascular bed from sinoaortic denervated rats to norepinephrine, methoxamine and verapamil
Braz. j. med. biol. res
;
21(3): 629-32, Mar. 1988. tab
Article
Dans Anglais
| LILACS
| ID: lil-60260
ABSTRACT
The contractile reactivity to noropinephrine, methoxamine, and verapamil of the perfused mesenteric vascular bed from sinoaortic denervated (SAD) and sham-operated (SO) rats was studied 3 to 30 days after surgery. A gradual but incomplete reduction of arterial hypertension was observed in SAD rats throughout the study. The norepinephrine-and methoxamine-induced dose-response curves were similar in both SAD and SO groups on day 3, but shifted to the left on days 7 and 15 and demonstrated a tendency to shift to the right at 30 days. Verapamil-induced vasodilation was similar in both groups. Enhanced mesenteric vascular responsiveness to endogenous catecholamines could contribute to the increased vascular resistance
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Indice:
LILAS (Amériques)
Sujet Principal:
Sinus de l'aorte
/
Circulation splanchnique
/
Vérapamil
/
Norépinéphrine
/
Dénervation
/
Méthoxamine
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1988
Type:
Article
/
Congrès et conférence
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