Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínico / Thalidomide for recurrent gastrointestinal bleeding caused by angiodysplasia: Report of one case
Rev. méd. Chile
;
139(7): 909-913, jul. 2011.
Article
Dans Espagnol
| LILACS
| ID: lil-603144
ABSTRACT
Chronic hemodialysis patients may have recurrent bleeding from gastrointestinal angiodysplasia, that often is diffusely located in the digestive tract or in places difficult to reach with traditional endoscopes. Therefore, they cannot be locally treated or removed. We report a 70 years old man on chronic hemodialysis, with severe and persistent anemia due to bleeding from angiodysplasia of the small bowel. Despite administration of high doses of erythropoiesis stimulating agents, intravenous iron, folate, B6 and B12 vitamins, his hemoglobin levels were < 6.5g/dL, becoming totally dependent on transfusions ofred blood cells (up to 46 units per year). Recurrent bleeding was refractory to conventional management and we decided to use thalidomide at doses of 50-100 mg/day achieving rapid control of gastrointestinal bleeding and significant increase of hemoglobin levels, not requiring further transfusions.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Thalidomide
/
Angiodysplasie
/
Inhibiteurs de l'angiogenèse
/
Hémorragie gastro-intestinale
/
Intestins
Type d'étude:
Etude d'étiologie
Limites du sujet:
Adulte très âgé
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2011
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Hospital Naval Almirante Nef/CL
/
Universidad de Valparaíso/CL
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