STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
Braz. j. med. biol. res
;
44(11): 1080-1087, Nov. 2011. ilus
Article
Dans Anglais
| LILACS
| ID: lil-604269
ABSTRACT
Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Canaux calciques
/
Calcium
/
Signalisation calcique
/
Protéines membranaires
/
Protéines tumorales
Type d'étude:
Étude pronostique
/
Revues systématiques évaluées
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2011
Type:
Article
Pays d'affiliation:
Brésil
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
Georgia Heath Science University/US
/
Universidade de São Paulo/BR
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