Mechanical evaluation of the resistance and elastance of post-burn scars after topical treatment with tretinoin
Clinics
;
66(11): 1949-1954, 2011. ilus
Article
Dans Anglais
| LILACS
| ID: lil-605877
ABSTRACT
OBJECTIVE:
After burn injuries, scarred skin lacks elasticity, especially in hypertrophic scars. Topical treatment with tretinoin can improve the appearance and quality of the skin (i.e., texture, distensibility, color, and hydration). The objective of this prospective study was to examine the effects of treatment with 0.05 percent tretinoin for one year on the biomechanical behavior and histological changes undergone by facial skin with post-burn scarring.Setting:
Tertiary, Institutional.METHOD:
Fifteen female patients who had suffered partial thickness burns with more than two years of evolution were selected. Skin biopsies were obtained initially and after one year of treatment. The resistance and elastance of these skin biopsies were measured using a mechanical oscillation analysis system. The density of collagen fibers, elastic fibers, and versican were determined using immunohistochemical analysis.RESULTS:
Tretinoin treatment significantly lowered skin resistance and elastance, which is a result that indicates higher distensibility of the skin. However, tretinoin treatment did not significantly affect the density of collagen fibers, elastic fibers, or versican.CONCLUSION:
Topical tretinoin treatment alters the mechanical behavior of post-burn scarred skin by improving its distensibility and thus leads to improved quality of life for patients.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Trétinoïne
/
Brûlures
/
Cicatrice hypertrophique
/
Élasticité
/
Lésions traumatiques de la face
/
Kératolytiques
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2011
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
University of São Paulo/BR
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