Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
Genet. mol. biol
;
34(4): 539-545, 2011. tab
Article
Dans Anglais
| LILACS
| ID: lil-605936
ABSTRACT
Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Polymorphisme génétique
/
Caractéristiques de la population
/
Système ABO de groupes sanguins
/
Haplotypes
/
Brésil
/
Récepteurs au C3b du complément
/
Écosystème Amazonien
/
Paludisme
Type d'étude:
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Genet. mol. biol
Thème du journal:
Génétique
Année:
2011
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
Hemocentro do Amazonas/BR
/
Iowa State University/US
/
Santa Casa de São Paulo/BR
/
Universidade Federal de São Paulo/BR
/
Universidade de São Paulo/BR
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