Reactivity of macro-and microvessels of doca-salt hypertensive rats: role of the endothelial cell
Braz. j. med. biol. res
;
21(4): 845-9, 1988. ilus
Article
Dans Anglais
| LILACS
| ID: lil-60806
ABSTRACT
The responses to noradrenaline (NA) and acetylcholine (ACh) of aortae and microvessels were cocmpared in control and DOCA-salt hypertensive rats. Macro - and microvessels from hypertensive rats showed an increased response to NA and a decreased response to ACh (an endothelium-dependent vasodilator). Unlike ACh, sodium nitroprusside (an endothelium-independent agent), was equally effective in evoking a vasodilator response from aortae and microvessels of hypertensive rats. These data suggest that the impaired response to ACh and the increased response to NA in DOCA-salt hypertension may result from an alteration of endothelial cell function
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Indice:
LILAS (Amériques)
Sujet Principal:
Aorte
/
Endothélium vasculaire
/
Acétylcholine
/
Norépinéphrine
/
Désoxycorticostérone
/
Hypertension artérielle
/
Artères mésentériques
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1988
Type:
Article
/
Congrès et conférence
/
descriptif de projet
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