Cáncer medular de tiroides esporádico de curso agresivo, en un adolescente varón / Madullary thyroid cancer in a 14 years old male: case report
Rev. chil. endocrinol. diabetes
;
3(2): 131-134, abr. 2010. ilus, graf
Article
Dans Espagnol
| LILACS
| ID: lil-610289
ABSTRACT
Medullary thyroid cancer can appear sporadically or as part of a multiple endocrine neoplasia type 2A or 2B. In both conditions, it is associated with mutations of proto oncogene RET (rearranged during transfection). We report a 14 years old male presenting with a bone lesion in the skull followed by a hard cevical mass. A CAT scan showed an invasive thyroid nodule with involvement of regional lymph nodes , osteolytic lesions in skull, spine and ribs and liver metastases. Serum calcitonin was markedly elevated (9752 pg/ml, normal below 14 pg/ml). Fine needle biopsy showed a medullary thyroid carcinoma and the patient was subjected to a total thyroidectomy and radical cervical dissection. In the postoperative period the patient required calcium and vitamin D supplementation. Serum calcitonin 15 days after surgery was 11.692 pg/ml. Palliative radiotherapy was indicated for spine pain. A percutaneous gastrostomy was indication for nutritional support. The molecular study did not detect mutations of RET gene between exons 10 and 16.
Recherche sur Google
Indice:
LILAS (Amériques)
Sujet Principal:
Tumeurs de la thyroïde
/
Carcinome médullaire
Limites du sujet:
Adolescent
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Rev. chil. endocrinol. diabetes
Thème du journal:
Endocrinologie
Année:
2010
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Pontificia Universidad Católica de Chile/CL
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS