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Síndrome metabólico en niñas púberes con hiperplasia suprarrenal congénita clásica / Metabolic syndrome among puberal girls with classic congenital adrenal hyperplasia
Ugarte P., Francisca; Gallardo T., Vivian; Sepúlveda R., Carolina; Codner D., Ethel; Iñiguez V., Germán; Villanueva T., Soledad; Alonso T., Faustino.
  • Ugarte P., Francisca; Hospital Exequiel González Cortés. Endocrinología Infantil. CL
  • Gallardo T., Vivian; Universidad de Chile. Escuela de Postgrado. CL
  • Sepúlveda R., Carolina; Universidad de Chile. Instituto de Investigaciones Materno Infantil. CL
  • Codner D., Ethel; Hospital Exequiel González Cortés. Endocrinología Infaltil. CL
  • Iñiguez V., Germán; Universidad de Chile. Instituto de Investigaciones Materno Infantil. CL
  • Villanueva T., Soledad; Hospital Exequiel González Cortés. Unidad de Endocrinología. CL
  • Alonso T., Faustino; Universidad de Chile. Facultad de Medicina. Escuela de Salud Pública. Departamento de Epidemiología. CL
Rev. chil. endocrinol. diabetes ; 3(2): 121-126, abr. 2010. tab
Article Dans Espagnol | LILACS | ID: lil-610290
ABSTRACT

Background:

Adult women with adrenal congenital hyperplasia (AH) have a higher risk for insulin resistance, dyslipidemia, hypertension, high body mass index (BMI) and increased body fat. All these factors are associated with cardiovascular risk and metabolic syndrome (MS).

Aim:

To evaluate the presence of MS in pubertal classic AH girls (CAH) and a control group (C). Material and

Methods:

We studied 15 pubertal AH patients (12.0 +/- 1.9 years) and 26 controls (11.7+/- 0.3 years) matched by age and tanner stage. Weight, height, BMI, waist/hip ratio, blood pressure and serum lipids were measured. An oral glucose tolerance test (OGTT) and insulin curve was performed in CAH girls whereas in controls basal insulin and glucose were determined. The homeostasis model assessment for insulin resistance (HOMAIR) was calculated. Cook, Ferranti and international diabetes federation (IDF) criteria were used to determine the presence of MS.

Results:

CAH and C girls had similar BMI (22.0 +/- 5.1 and 20.1 +/- 3.6 kg/m2 respectively; p = 0,11). CAH girls had higher basal blood glucose (80.8 +/- 7.7 and 60.6 +/- 10.6 mg/dl respectively, p < 0.01) and controls had higher triglyceride levels (147.0 +/- 69.3 and 79.7 +/-16.3 mg/dl respectively, p < 0.01) and lower HDL cholesterol levels (45.8 +/- 12.8 and 56.9 +/- 17.5 mg/dl respectively, p = 0.02). According to cook criteria 4 percent of CAH girls and 23 percent of controls has MS. These figures were 14 and 32 percent respectively according to Ferranti criteria and 0 and 5 percent respectively according to IDF criteria.

Conclusions:

CAH puberal patients do not have a higher prevalence of metabolic syndrome, compared with controls with similar Tanner stage and BMI.
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Indice: LILAS (Amériques) Sujet Principal: Hyperplasie congénitale des surrénales / Syndrome métabolique X Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Enfant / Femelle / Humains langue: Espagnol Texte intégral: Rev. chil. endocrinol. diabetes Thème du journal: Endocrinologie Année: 2010 Type: Article Pays d'affiliation: Chili Institution/Pays d'affiliation: Hospital Exequiel González Cortés/CL / Universidad de Chile/CL

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Recherche sur Google
Indice: LILAS (Amériques) Sujet Principal: Hyperplasie congénitale des surrénales / Syndrome métabolique X Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Enfant / Femelle / Humains langue: Espagnol Texte intégral: Rev. chil. endocrinol. diabetes Thème du journal: Endocrinologie Année: 2010 Type: Article Pays d'affiliation: Chili Institution/Pays d'affiliation: Hospital Exequiel González Cortés/CL / Universidad de Chile/CL