Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
Mem. Inst. Oswaldo Cruz
;
106(8): 1045-1048, Dec. 2011. tab
Article
Dans Anglais
| LILACS
| ID: lil-610984
ABSTRACT
The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Triazoles
/
Association triméthoprime-sulfaméthoxazole
/
Coccidioides
/
Antifongiques
Type d'étude:
Guide de pratique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2011
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de São Paulo/BR
/
Universidade Federal do Ceará/BR
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