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A survey on pulmonary pathogens and their antibiotic susceptibility among cystic fibrosis patients
Khanbabaee, Ghamartaj; Akbarizadeh, Majidreza; Sayyari, Aliakbar; Ashayeri-Panah, Mitra; Abdollahgorji, Fatemeh; Sheibani, Kourosh; Rezaeig, Nima.
  • Khanbabaee, Ghamartaj; Shahid Beheshti University of Medical Sciences. Mofid Children Hospital. CF Center. Department Pediatric Respiratory Diseases. Tehran. IR
  • Akbarizadeh, Majidreza; Zabol University of Medical Sciences. Department of Pediatrics. Zabol. IR
  • Sayyari, Aliakbar; Shahid Beheshti University of Medical Sciences. Mofid Children Hospital. CF Center. Department of Pediatric Gastroenterology Diseases. Tehran. IR
  • Ashayeri-Panah, Mitra; Shahid Beheshti University. Faculty of Biological Sciences. Department of Microbiology. Tehran. IR
  • Abdollahgorji, Fatemeh; Shahid Beheshti University of Medical Sciences. Mofid Children Hospital. Clinical Research and Development Center. Tehran. IR
  • Sheibani, Kourosh; Shahid Beheshti University of Medical Sciences. Imam Hossein Medical Center. Clinical Research and Development Center. Tehran. IR
  • Rezaeig, Nima; Research Center for Immunodeficiencies.
Braz. j. infect. dis ; 16(2): 122-128, May-Apr. 2012. ilus, tab
Article Dans Anglais | LILACS | ID: lil-622731
ABSTRACT

OBJECTIVE:

This study was performed to investigate frequency and antimicrobial susceptibility of pulmonary pathogens in cystic fibrosis (CF) patients.

METHODS:

129 pediatric patients with CF were enrolled in this cross-sectional study. Microbiological cultures were performed based on sputum or pharyngeal swabs. Antibiotic susceptibilities of the isolated bacteria were determined by the disk diffusion method.

RESULTS:

The main infecting pathogens were Pseudomonas aeruginosa (38.8%), Klebsiella pneumoniae (11.6%) and Staphyloccus areus (9.3%), respectively. The most active antibiotics included rifampin (91.7% susceptibility), vancomycin (85%) and imipenem (83.5%). Emerging resistance against aminoglycosides was observed.

CONCLUSION:

Regarding in vitro susceptibility results, cyclic treatment of long-term oral azithromycin and inhaled tobramycin could prophylactically be applied, and during exacerbations, imipenem or ceftazidime in combination with an aminoglycoside such as amikacin could be considered the drugs of choice.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Pharynx / Expectoration / Mucoviscidose / Bactéries à Gram négatif / Bactéries à Gram positif Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle langue: Anglais Texte intégral: Braz. j. infect. dis Thème du journal: Maladies transmissibles Année: 2012 Type: Article Pays d'affiliation: Iran Institution/Pays d'affiliation: Shahid Beheshti University of Medical Sciences/IR / Shahid Beheshti University/IR / Zabol University of Medical Sciences/IR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Pharynx / Expectoration / Mucoviscidose / Bactéries à Gram négatif / Bactéries à Gram positif Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle langue: Anglais Texte intégral: Braz. j. infect. dis Thème du journal: Maladies transmissibles Année: 2012 Type: Article Pays d'affiliation: Iran Institution/Pays d'affiliation: Shahid Beheshti University of Medical Sciences/IR / Shahid Beheshti University/IR / Zabol University of Medical Sciences/IR