A survey on pulmonary pathogens and their antibiotic susceptibility among cystic fibrosis patients
Braz. j. infect. dis
;
16(2): 122-128, May-Apr. 2012. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-622731
ABSTRACT
OBJECTIVE:
This study was performed to investigate frequency and antimicrobial susceptibility of pulmonary pathogens in cystic fibrosis (CF) patients.METHODS:
129 pediatric patients with CF were enrolled in this cross-sectional study. Microbiological cultures were performed based on sputum or pharyngeal swabs. Antibiotic susceptibilities of the isolated bacteria were determined by the disk diffusion method.RESULTS:
The main infecting pathogens were Pseudomonas aeruginosa (38.8%), Klebsiella pneumoniae (11.6%) and Staphyloccus areus (9.3%), respectively. The most active antibiotics included rifampin (91.7% susceptibility), vancomycin (85%) and imipenem (83.5%). Emerging resistance against aminoglycosides was observed.CONCLUSION:
Regarding in vitro susceptibility results, cyclic treatment of long-term oral azithromycin and inhaled tobramycin could prophylactically be applied, and during exacerbations, imipenem or ceftazidime in combination with an aminoglycoside such as amikacin could be considered the drugs of choice.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Pharynx
/
Expectoration
/
Mucoviscidose
/
Bactéries à Gram négatif
/
Bactéries à Gram positif
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Bébé
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. infect. dis
Thème du journal:
Maladies transmissibles
Année:
2012
Type:
Article
Pays d'affiliation:
Iran
Institution/Pays d'affiliation:
Shahid Beheshti University of Medical Sciences/IR
/
Shahid Beheshti University/IR
/
Zabol University of Medical Sciences/IR
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