Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats
J. venom. anim. toxins incl. trop. dis
;
17(4): 422-429, 2011. ilus, tab
Article
Dans Anglais
| LILACS, VETINDEX
| ID: lil-623505
ABSTRACT
Wasp venom is mixture of complex proteins that have several physical and pharmacological properties. The photochemical detoxification of Vespa orientalis venom is expected to generate photooxidized venom sac extract (PVSE). Antigenically active PVSE is obtained by exposing the venom sac extract (VSE) of Vespa orientalis to ultraviolet radiation in the presence of methylene blue. The aim of the present work was to evaluate the effect of PVSE on learning and memory of rats. Detoxification of PVSE was evident since treated mice had longer survival time than the group of mice treated with VSE. Photooxidized VSE of V. orientalis revealed enhancement on learning and memory by shortening the time to reach food (TRF) in T-maze. In a 28-day study with rats, we observed that PVSE significantly decreased transfer latency (TL) in elevated plus maze (EPM), significantly increased step down latency (SDL), diminished step down errors (SDE) and time spent in shock zone (TSS) in step down avoidance test. Thus, we concluded that although there is a possibility of employing PVSE in the treatment of Alzheimer, dementia or neurodegenerative illness as a non-herbal and non-synthetic alternative for patients who do not respond to available therapy, further investigation is still required.(AU)
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Venins de guêpe
/
Photooxidation
/
Test du labyrinthe en croix surélevé
/
Mémoire
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. venom. anim. toxins incl. trop. dis
Année:
2011
Type:
Article
Institution/Pays d'affiliation:
PES College of Pharmacy/IN
/
SVERI's College of Pharmacy/IN
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