The role of thymic accessory cells in cytokine production and in the intra-thymic T cell differentiation pathway
Mem. Inst. Oswaldo Cruz
;
82(supl.2): 23-28, 1987. ilus, graf
Article
Dans Anglais
| LILACS
| ID: lil-623760
ABSTRACT
Intrathymic T lymphocyte differentiation proceeds from complex interactions between prothymocytes of bone marrow origin and cells of the thymic stroma, epithelial cells and "acessory" cells (macrophages and/or interdigitating cells). The present paper describes the role of the accessoty cell compartment in this intrathymic process. Acessory cells produce factors which are involved in thymocyte proliferation (interleukin 1, prostaglandins, deoxynucleosides). Cell-cell interaction between "accessory" cells and thymocytes is required for the regulation of interleukin production. Prothymocytes, the precursors of all thymocyte subsets, need the accessory cell compartment for their IL2 dependent proliferation and their differentiation. Accessory cells of the thymic stroma may be involved in the intrathymic selection process at the prothymocyte level.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Facteur thymique sérique
/
Récepteurs aux cytokines
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
1987
Type:
Article
/
Congrès et conférence
Pays d'affiliation:
France
Institution/Pays d'affiliation:
INSERM U 25/FR
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