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Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents
Barbosa Filho, J. M; Agra, M. F; Oliveira, R. A. G; Paulo, M. Q; Trolin, G; Cunha, E. V. L; Ataide, J. R; Bhattacharyya, J.
  • Barbosa Filho, J. M; Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa. BR
  • Agra, M. F; Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa. BR
  • Oliveira, R. A. G; Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa. BR
  • Paulo, M. Q; Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa. BR
  • Trolin, G; Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa. BR
  • Cunha, E. V. L; Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa. BR
  • Ataide, J. R; Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa. BR
  • Bhattacharyya, J; Southeastern Massachusetts University. Department of Chemistry. N Dartmouth. US
Mem. Inst. Oswaldo Cruz ; 86(supl.2): 189-191, 1991. ilus, tab
Article Dans Anglais | LILACS | ID: lil-623968
ABSTRACT
A systematic search for solasodine, an important staring material for the partial synthesis of steroidal hormones as well as other potentially bioactive constituents of various Solanum species of Brazil has been undertaken. Thus, the fruits of S. paludosum, S. asperum, S. sessiliforum and Solanum sp. were found to contain significant amounts of solasodine. The root bark of S. paludosum which showe durare like activity yelded tomatidenol and another yet unidentified alkaloid responsible for the biological activity. The fruits of S. asperum yelded a new spirosolane alkaloid, solaparnaine. The stem bark of S. pseudo-quina showed convulsive and exitatory activity from which (25S)-isosolafloridine was identified as the active principle. In addition, the latter alkaloid was also found to show antimicrobial activity.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Plantes médicinales / Alcaloïdes des Solanaceae / Stéroïdes Limites du sujet: Humains Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 1991 Type: Article / Congrès et conférence Pays d'affiliation: Brésil / États-Unis d'Amérique Institution/Pays d'affiliation: Southeastern Massachusetts University/US / Universidade Federal da Paraíba/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Plantes médicinales / Alcaloïdes des Solanaceae / Stéroïdes Limites du sujet: Humains Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Mem. Inst. Oswaldo Cruz Thème du journal: Médecine tropicale / Parasitologie Année: 1991 Type: Article / Congrès et conférence Pays d'affiliation: Brésil / États-Unis d'Amérique Institution/Pays d'affiliation: Southeastern Massachusetts University/US / Universidade Federal da Paraíba/BR