The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates
Mem. Inst. Oswaldo Cruz
;
107(3): 433-436, May 2012. tab
Article
Dans Anglais
| LILACS
| ID: lil-624029
ABSTRACT
The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Pyrimidines
/
Triazoles
/
Fluconazole
/
Amphotéricine B
/
Candida glabrata
/
Échinocandines
/
Antifongiques
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2012
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Complexo Hospitalar Santa Casa de Misericórdia/BR
/
Universidade Federal de Santa Maria/BR
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