E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
Rev. clín. periodoncia implantol. rehabil. oral (Impr.)
;
4(3): 122-125, dic. 2011. ilus
Article
Dans Anglais
| LILACS
| ID: lil-627549
ABSTRACT
Objective:
The aim of this study was to assess epithelial expression of E-cadherin and c-Met in normal lip, in actinic cheilitis and lip squamous cell carcinoma. StudyDesign:
Biopsies of normal lip vermillion (NL, n=18), actinic cheilitis (AC, n=37), and lip SCC (n=22) were processed for E-cadherin and c-Met immunodetection. Epithelial and tumor cell expression was scored for each sample considering staining intensity and percentage.Results:
E-cadherin expression was significantly reduced in AC and lip SCC as compared to normal lip (P<0.05), with a significant reduction in lip SCC as compared to AC (P=0.003). Expression of c-Met was significantly higher in AC and lip SCC as compared to NL (P<0.05), with a significant increase in lip SCC as compared to AC (P<0.0001).Conclusion:
The results showed that epithelial E-cadherin expression is reduced and c-Met expression is increased as lip carcinogenesis progresses, suggesting that these proteins may be useful markers of malignant transformation.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tumeurs de la lèvre
/
Carcinome épidermoïde
/
Cadhérines
/
Chéilite
/
Protéines proto-oncogènes c-met
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Rev. clín. periodoncia implantol. rehabil. oral (Impr.)
Thème du journal:
Dentisterie
Année:
2011
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
University of Concepción/CL
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