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Effect of N-acetylcysteine on pulmonary cell death in a controlled hemorrhagic shock model in rats / Efeito da N-acetilcisteína na morte celular pulmonar em um modelo de choque hemorrágico controlado em ratos
Saad, Paulo Fernandes; Saad, Karen Ruggeri; Oliveira Filho, Luiz Dantas de; Ferreira, Sueli Gomes; Koike, Marcia Kiyomi; Montero, Edna Frasson de Souza.
  • Saad, Paulo Fernandes; Sao Francisco Valley Federal University. Faculty of Medicine.
  • Saad, Karen Ruggeri; Sao Francisco Valley Federal University. Faculty of Medicine.
  • Oliveira Filho, Luiz Dantas de; Sao Francisco Valley Federal University. Faculty of Medicine.
  • Ferreira, Sueli Gomes; Sao Francisco Valley Federal University. Faculty of Medicine.
  • Koike, Marcia Kiyomi; Sao Francisco Valley Federal University. Faculty of Medicine.
  • Montero, Edna Frasson de Souza; USP. Faculty of Medicine. Sao Paulo. BR
Acta cir. bras ; 27(8): 561-565, Aug. 2012. ilus
Article Dans Anglais | LILACS | ID: lil-643625
ABSTRACT

PURPOSE:

To evaluate the effect of N-acetylcysteine (NAC) combined with fluid resuscitation on pulmonary cell death in rats induced with controlled hemorrhagic shock (HS).

METHODS:

Two arteries (MAP calculation and exsanguination) and one vein (treatments) were catheterized in 22 anesthetized rats. Two groups of male albino rats were induced with controlled HS at 35mmHg MAP for 60 min. After this period, the RL group was resuscitated with Ringer's lactate and the RL+NAC group was resuscitated with Ringer's lactate combined with 150mg/Kg NAC. The control group animals were cannulated only. The animals were euthanized after 120 min of fluid resuscitation. Lung tissue samples were collected to evaluate the following histopathology, TUNEL and imunohistochemical expression of caspase 3.

RESULTS:

RL showed a greater number of cells stained by TUNEL than RL + NAC, but there was no change in caspase 3 expression in any group.

CONCLUSION:

N-acetylcysteine associate to fluid resuscitation, after hemorrhagic shock, decreased cell death attenuating lung injury.
RESUMO

OBJETIVO:

Avaliar o efeito da N-acetilcisteína (NAC) combinada ao fluido de reposição volêmica na morte celular pulmonar de ratos submetidos ao choque hemorrágico (CH) controlado.

MÉTODOS:

Duas artérias (cálculo da PAM e exsanguinação) e uma veia (tratamentos) foram cateterizadas em 22 ratos anestesiados. Dois grupos de ratos machos albinos foram induzidos ao CH controlado com PAM de 35mmHg por 60 min. Após este período, o grupo RL foi ressuscitado com Ringer lactato e o grupo RL+NAC foi ressuscitado com Ringer lactato associado com 150mg/Kg de NAC. O grupo controle sofreu somente o procedimento cirúrgico de cateterização. Os animais sofreram eutanásia após 120 min. da ressuscitação. Amostras de tecido pulmonar foram coletadas para histopatologia, TUNEL e a imuno-expressão da caspase 3.

RESULTADOS:

RL apresentou maior número de células marcadas pelo TUNEL do que RL+NAC, porém sem alteração na expressão da caspase 3 em nenhum dos grupos estudados.

CONCLUSÃO:

A N-acetilcisteína teve um papel protetor na morte celular em modelo de choque hemorrágico controlado.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Acétylcystéine / Réanimation / Choc hémorragique / Mort cellulaire / Poumon Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2012 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: USP/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Acétylcystéine / Réanimation / Choc hémorragique / Mort cellulaire / Poumon Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2012 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: USP/BR