Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
Mem. Inst. Oswaldo Cruz
;
107(6): 713-719, set. 2012. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-649484
ABSTRACT
Protein tyrosine phosphatases (PTPs) play an essential role in the regulation of cell differentiation in pathogenic trypanosomatids. In this study, we describe a PTP expressed by the non-pathogenic protozoan Trypanosoma rangeli (TrPTP2). The gene for this PTP is orthologous to the T. brucei TbPTP1 and Trypanosoma cruzi (TcPTP2) genes. Cloning and expression of the TrPTP2 and TcPTP2 proteins allowed anti-PTP2 monoclonal antibodies to be generated in BALB/c mice. When expressed by T. rangeli epimastigotes and trypomastigotes, native TrPTP2 is detected as a ~65 kDa protein associated with the parasite's flagellum. Given that the flagellum is an important structure for cell differentiation in trypanosomatids, the presence of a protein responsible for tyrosine dephosphorylation in the T. rangeli flagellum could represent an interesting mechanism of regulation in this structure.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Protein Tyrosine Phosphatases
/
Trypanosoma rangeli
/
Flagelles
/
Anticorps monoclonaux
Type d'étude:
Facteurs de risque
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2012
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fiocruz/BR
/
Universidade Federal de Santa Catarina/BR
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